Drug interactions
Fexinidazole + Fluticasone-vilanterol
Severity: Moderate
Fexinidazole and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may increase exposure to vilanterol and fluticasone furoate; it also prolongs the QT interval. This can heighten beta-agonist cardiovascular effects and arrhythmia risk.
What this interaction means in plain words
Fexinidazole and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition reducing vilanterol and fluticasone clearance, plus additive QT effects.
What to do
Monitor ECG, heart rate and potassium during the short fexinidazole course. Watch for tremor, palpitations and corticosteroid effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Frequently asked questions
Can I take Fexinidazole with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Fexinidazole and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and may increase exposure to vilanterol and fluticasone furoate; it also prolongs the QT interval. This can heighten beta-agonist cardiovascular effects and arrhythmia risk.
How serious is the interaction between Fexinidazole and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, heart rate and potassium during the short fexinidazole course. Watch for tremor, palpitations and corticosteroid effects.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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