Drug interactions
Fexinidazole + Hydrochlorothiazide-losartan
Severity: Moderate
Fexinidazole and Hydrochlorothiazide-losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and could modestly raise exposure to CYP3A4 substrates. Losartan is converted to its active metabolite partly by CYP3A4 and CYP2C9, so the net effect on blood pressure is unpredictable and likely small. Fexinidazole also prolongs the QT interval, but losartan and hydrochlorothiazide do not share that effect, apart from electrolyte disturbance from the thiazide.
What this interaction means in plain words
Fexinidazole and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP3A4 inhibition by fexinidazole altering losartan activation; thiazide-induced hypokalemia or hypomagnesemia may add QT risk.
What to do
Monitor blood pressure and check potassium and magnesium before and during fexinidazole treatment, correcting abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Fexinidazole with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as moderate. Fexinidazole and Hydrochlorothiazide-losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and could modestly raise exposure to CYP3A4 substrates. Losartan is converted to its active metabolite partly by CYP3A4 and CYP2C9, so the net effect on blood pressure is unpredictable and likely small. Fexinidazole also prolongs the QT interval, but losartan and hydrochlorothiazide do not share that effect, apart from electrolyte disturbance from the thiazide.
How serious is the interaction between Fexinidazole and Hydrochlorothiazide-losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and check potassium and magnesium before and during fexinidazole treatment, correcting abnormalities.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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