Drug interactions
Fexinidazole + Hydrocodone
Severity: Moderate
Fexinidazole and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4, the main pathway for hydrocodone clearance, and may raise hydrocodone concentrations. This increases the risk of sedation and respiratory depression.
What this interaction means in plain words
Fexinidazole and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by fexinidazole reduces hydrocodone metabolism.
What to do
Monitor for sedation and respiratory depression during fexinidazole treatment and reduce the hydrocodone dose if needed. Fexinidazole is given as a short course under supervision.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Frequently asked questions
Can I take Fexinidazole with Hydrocodone?
MediHelp rates the interaction as moderate. Fexinidazole and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4, the main pathway for hydrocodone clearance, and may raise hydrocodone concentrations. This increases the risk of sedation and respiratory depression.
How serious is the interaction between Fexinidazole and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression during fexinidazole treatment and reduce the hydrocodone dose if needed. Fexinidazole is given as a short course under supervision.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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