Drug interactions
Fexinidazole + Imatinib
Severity: Moderate
Fexinidazole and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may raise imatinib concentrations. Fexinidazole itself can prolong the QT interval, and imatinib has some QT effect, so toxicity may be additive.
What this interaction means in plain words
Fexinidazole and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4-mediated imatinib metabolism, with possible additive QT effects.
What to do
Monitor for imatinib toxicity and obtain an ECG with electrolyte checks during fexinidazole therapy; consider an imatinib dose reduction if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Fexinidazole with Imatinib?
MediHelp rates the interaction as moderate. Fexinidazole and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and may raise imatinib concentrations. Fexinidazole itself can prolong the QT interval, and imatinib has some QT effect, so toxicity may be additive.
How serious is the interaction between Fexinidazole and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib toxicity and obtain an ECG with electrolyte checks during fexinidazole therapy; consider an imatinib dose reduction if adverse effects emerge.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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