Drug interactions
Fexinidazole + Lidocaine-prilocaine
Severity: Minor
Fexinidazole and Lidocaine-prilocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP1A2, which contributes to lidocaine clearance, potentially increasing lidocaine levels. Topical lidocaine-prilocaine yields low systemic exposure, so clinical impact is expected to be small; fexinidazole itself also prolongs QT.
What this interaction means in plain words
Fexinidazole and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of CYP1A2-mediated lidocaine metabolism by fexinidazole.
What to do
Use labeled doses on limited areas of intact skin. Monitor for signs of lidocaine toxicity if extensive application is unavoidable.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Frequently asked questions
Can I take Fexinidazole with Lidocaine-prilocaine?
MediHelp rates the interaction as minor. Fexinidazole and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fexinidazole may inhibit CYP1A2, which contributes to lidocaine clearance, potentially increasing lidocaine levels. Topical lidocaine-prilocaine yields low systemic exposure, so clinical impact is expected to be small; fexinidazole itself also prolongs QT.
How serious is the interaction between Fexinidazole and Lidocaine-prilocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use labeled doses on limited areas of intact skin. Monitor for signs of lidocaine toxicity if extensive application is unavoidable.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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