Drug interactions
Fexinidazole + Mexiletine
Severity: Moderate
Fexinidazole and Mexiletine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites may inhibit CYP1A2, potentially raising mexiletine concentrations. Fexinidazole also prolongs the QT interval, adding a pharmacodynamic concern with an antiarrhythmic.
What this interaction means in plain words
Fexinidazole and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP1A2 inhibition reduces mexiletine clearance, with possible additive cardiac effects.
What to do
Monitor ECG and for mexiletine toxicity during the fexinidazole course, and correct electrolytes. Reduce the mexiletine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Frequently asked questions
Can I take Fexinidazole with Mexiletine?
MediHelp rates the interaction as moderate. Fexinidazole and Mexiletine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites may inhibit CYP1A2, potentially raising mexiletine concentrations. Fexinidazole also prolongs the QT interval, adding a pharmacodynamic concern with an antiarrhythmic.
How serious is the interaction between Fexinidazole and Mexiletine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for mexiletine toxicity during the fexinidazole course, and correct electrolytes. Reduce the mexiletine dose if toxicity appears.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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