Drug interactions
Fexinidazole + Nadolol
Severity: Major
Fexinidazole and Nadolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval and cause bradycardia-related arrhythmia risk, and beta-blockers add bradycardia. The combination increases the likelihood of torsades de pointes.
What this interaction means in plain words
Fexinidazole and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive bradycardia from nadolol raises proarrhythmic risk in the setting of fexinidazole QT prolongation.
What to do
Avoid coadministration where possible. If unavoidable, monitor ECG, heart rate and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Fexinidazole with Nadolol?
MediHelp rates the interaction as major. Fexinidazole and Nadolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval and cause bradycardia-related arrhythmia risk, and beta-blockers add bradycardia. The combination increases the likelihood of torsades de pointes.
How serious is the interaction between Fexinidazole and Nadolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible. If unavoidable, monitor ECG, heart rate and electrolytes closely.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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