Drug interactions
Fexinidazole + Nicardipine
Severity: Moderate
Fexinidazole and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites may inhibit CYP3A4 and could increase nicardipine exposure, causing hypotension, flushing and tachycardia. Fexinidazole is also given for a short course with food and carries QT concerns, so additive cardiovascular effects matter.
What this interaction means in plain words
Fexinidazole and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, decreasing nicardipine metabolism.
What to do
Monitor blood pressure and heart rate during the fexinidazole course and reduce the nicardipine dose if hypotension occurs. Consider a temporary alternative antihypertensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Fexinidazole with Nicardipine?
MediHelp rates the interaction as moderate. Fexinidazole and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites may inhibit CYP3A4 and could increase nicardipine exposure, causing hypotension, flushing and tachycardia. Fexinidazole is also given for a short course with food and carries QT concerns, so additive cardiovascular effects matter.
How serious is the interaction between Fexinidazole and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during the fexinidazole course and reduce the nicardipine dose if hypotension occurs. Consider a temporary alternative antihypertensive.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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