Drug interactions
Fexinidazole + Nimodipine
Severity: Moderate
Fexinidazole and Nimodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites inhibit CYP3A4 and may increase nimodipine concentrations. This raises the risk of hypotension, flushing and headache.
What this interaction means in plain words
Fexinidazole and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing nimodipine metabolism.
What to do
Monitor blood pressure and heart rate during the fexinidazole course, and reduce the nimodipine dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nimodipine
- Apalutamide + Nimodipine Major
- Carbamazepine + Nimodipine Major
- Ceritinib + Nimodipine Major
- Clarithromycin + Nimodipine Major
- Cobicistat + Nimodipine Major
- Darunavir + Nimodipine Major
Frequently asked questions
Can I take Fexinidazole with Nimodipine?
MediHelp rates the interaction as moderate. Fexinidazole and Nimodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites inhibit CYP3A4 and may increase nimodipine concentrations. This raises the risk of hypotension, flushing and headache.
How serious is the interaction between Fexinidazole and Nimodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during the fexinidazole course, and reduce the nimodipine dose if hypotension occurs.
What other medicines interact with Nimodipine?
MediHelp also lists interactions of Nimodipine with, for example, Apalutamide, Carbamazepine, Ceritinib. The full list is on the Nimodipine page.
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