Drug interactions
Fexinidazole + Ramelteon
Severity: Moderate
Fexinidazole and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP1A2 according to labeling concerns, which could increase exposure to ramelteon, a CYP1A2 substrate. Increased sedation and dizziness may result.
What this interaction means in plain words
Fexinidazole and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP1A2-mediated ramelteon metabolism.
What to do
Monitor for excessive sedation during the short fexinidazole course; consider holding ramelteon if it is not essential.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Fexinidazole with Ramelteon?
MediHelp rates the interaction as moderate. Fexinidazole and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP1A2 according to labeling concerns, which could increase exposure to ramelteon, a CYP1A2 substrate. Increased sedation and dizziness may result.
How serious is the interaction between Fexinidazole and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation during the short fexinidazole course; consider holding ramelteon if it is not essential.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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