Drug interactions
Fexinidazole + Regorafenib
Severity: Moderate
Fexinidazole and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites can inhibit CYP3A4, and regorafenib is cleared mainly through CYP3A4. Higher regorafenib parent exposure is possible, with greater risk of hepatotoxicity, hypertension and hand-foot skin reaction, while exposure to its active metabolites may fall. The clinical size of the effect is not well characterized.
What this interaction means in plain words
Fexinidazole and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of regorafenib by fexinidazole.
What to do
Avoid the combination where possible, as fexinidazole is given only as a short course. If both are needed, monitor liver function tests and blood pressure closely and watch for regorafenib toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fexinidazole and Regorafenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Regorafenib
Frequently asked questions
Can I take Fexinidazole with Regorafenib?
MediHelp rates the interaction as moderate. Fexinidazole and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites can inhibit CYP3A4, and regorafenib is cleared mainly through CYP3A4. Higher regorafenib parent exposure is possible, with greater risk of hepatotoxicity, hypertension and hand-foot skin reaction, while exposure to its active metabolites may fall. The clinical size of the effect is not well characterized.
How serious is the interaction between Fexinidazole and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, as fexinidazole is given only as a short course. If both are needed, monitor liver function tests and blood pressure closely and watch for regorafenib toxicity.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
