Drug interactions
Fexinidazole + Roflumilast
Severity: Moderate
Fexinidazole and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and raise roflumilast exposure. This may increase adverse effects such as diarrhea, weight loss, insomnia, headache and psychiatric symptoms.
What this interaction means in plain words
Fexinidazole and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, decreasing roflumilast metabolism.
What to do
Monitor for roflumilast adverse effects including gastrointestinal and psychiatric symptoms during the short fexinidazole course. Consider temporarily withholding roflumilast.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Roflumilast
Frequently asked questions
Can I take Fexinidazole with Roflumilast?
MediHelp rates the interaction as moderate. Fexinidazole and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and raise roflumilast exposure. This may increase adverse effects such as diarrhea, weight loss, insomnia, headache and psychiatric symptoms.
How serious is the interaction between Fexinidazole and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for roflumilast adverse effects including gastrointestinal and psychiatric symptoms during the short fexinidazole course. Consider temporarily withholding roflumilast.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
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