Drug interactions
Fexinidazole + Saxagliptin-metformin
Severity: Moderate
Fexinidazole and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole inhibits CYP3A4 and may raise saxagliptin exposure. The effect is likely moderate and is a short-course interaction.
What this interaction means in plain words
Fexinidazole and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4 metabolism of saxagliptin.
What to do
Monitor for saxagliptin adverse effects and glucose control during the fexinidazole course; consider reducing saxagliptin to 2.5 mg daily.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Fexinidazole with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Fexinidazole and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole inhibits CYP3A4 and may raise saxagliptin exposure. The effect is likely moderate and is a short-course interaction.
How serious is the interaction between Fexinidazole and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for saxagliptin adverse effects and glucose control during the fexinidazole course; consider reducing saxagliptin to 2.5 mg daily.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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