Drug interactions
Fexinidazole + Secobarbital
Severity: Major
Fexinidazole and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzyme inducers are expected to reduce fexinidazole activation and alter its metabolites, so efficacy against trypanosomiasis may be compromised. The labeling advises avoiding strong CYP inducers, and changes in metabolite exposure may affect QT risk.
What this interaction means in plain words
Fexinidazole and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Barbiturate induction of CYP enzymes alters the metabolism of fexinidazole and its sulfoxide and sulfone metabolites.
What to do
Avoid the combination and use a non-inducing sedative. If unavoidable, monitor ECG and treatment response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Fexinidazole with Secobarbital?
MediHelp rates the interaction as major. Fexinidazole and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzyme inducers are expected to reduce fexinidazole activation and alter its metabolites, so efficacy against trypanosomiasis may be compromised. The labeling advises avoiding strong CYP inducers, and changes in metabolite exposure may affect QT risk.
How serious is the interaction between Fexinidazole and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing sedative. If unavoidable, monitor ECG and treatment response.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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