Drug interactions
Fexinidazole + Tamsulosin
Severity: Moderate
Fexinidazole and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may raise tamsulosin exposure through CYP3A4 inhibition. Higher tamsulosin levels can cause orthostatic hypotension, dizziness and syncope.
What this interaction means in plain words
Fexinidazole and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated tamsulosin metabolism increases systemic exposure.
What to do
Monitor blood pressure and orthostatic symptoms during the short fexinidazole course, and counsel the patient about dizziness. Consider temporarily holding tamsulosin if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fexinidazole and Tamsulosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Frequently asked questions
Can I take Fexinidazole with Tamsulosin?
MediHelp rates the interaction as moderate. Fexinidazole and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may raise tamsulosin exposure through CYP3A4 inhibition. Higher tamsulosin levels can cause orthostatic hypotension, dizziness and syncope.
How serious is the interaction between Fexinidazole and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during the short fexinidazole course, and counsel the patient about dizziness. Consider temporarily holding tamsulosin if symptoms occur.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
