Drug interactions
Fexinidazole + Thioridazine
Severity: Contraindicated
Fexinidazole and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval, and thioridazine is a well-known QT-prolonging antipsychotic. Together they raise the risk of torsades de pointes and sudden death.
What this interaction means in plain words
Fexinidazole and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive hERG potassium channel blockade leading to delayed ventricular repolarization.
What to do
Avoid the combination; use an alternative antipsychotic with lower QT liability if treatment with fexinidazole is needed. If unavoidable, monitor ECG and correct electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Fexinidazole with Thioridazine?
MediHelp rates the interaction as contraindicated. Fexinidazole and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fexinidazole can prolong the QT interval, and thioridazine is a well-known QT-prolonging antipsychotic. Together they raise the risk of torsades de pointes and sudden death.
How serious is the interaction between Fexinidazole and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative antipsychotic with lower QT liability if treatment with fexinidazole is needed. If unavoidable, monitor ECG and correct electrolytes.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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