Drug interactions
Fexinidazole + Ticagrelor
Severity: Moderate
Fexinidazole and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and could raise ticagrelor exposure, increasing bleeding risk. Fexinidazole also prolongs the QT interval, but this is not related to ticagrelor.
What this interaction means in plain words
Fexinidazole and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 may reduce ticagrelor metabolism.
What to do
Monitor for bleeding and dyspnea during the short fexinidazole course. Consider an alternative antiplatelet if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Fexinidazole with Ticagrelor?
MediHelp rates the interaction as moderate. Fexinidazole and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and could raise ticagrelor exposure, increasing bleeding risk. Fexinidazole also prolongs the QT interval, but this is not related to ticagrelor.
How serious is the interaction between Fexinidazole and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and dyspnea during the short fexinidazole course. Consider an alternative antiplatelet if bleeding risk is high.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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