Drug interactions
Fexinidazole + Umeclidinium-vilanterol
Severity: Moderate
Fexinidazole and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole prolongs the QT interval and may inhibit CYP3A4, which could increase vilanterol exposure. Greater beta-agonist effect on top of QT prolongation may raise the risk of tachycardia and arrhythmia.
What this interaction means in plain words
Fexinidazole and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible CYP3A4 inhibition increasing vilanterol exposure, with additive QT and cardiac stimulatory effects.
What to do
Monitor heart rate, ECG and potassium during fexinidazole treatment, which is usually supervised. Reassess the need for the long-acting bronchodilator if cardiac symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Fexinidazole with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Fexinidazole and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole prolongs the QT interval and may inhibit CYP3A4, which could increase vilanterol exposure. Greater beta-agonist effect on top of QT prolongation may raise the risk of tachycardia and arrhythmia.
How serious is the interaction between Fexinidazole and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium during fexinidazole treatment, which is usually supervised. Reassess the need for the long-acting bronchodilator if cardiac symptoms occur.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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