Drug interactions
Fexinidazole + Vardenafil
Severity: Major
Fexinidazole and Vardenafil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole prolongs the QT interval and its label advises against combining it with other QT-prolonging drugs. Vardenafil adds a small QT effect, which may increase the risk of torsades de pointes.
What this interaction means in plain words
Fexinidazole and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid vardenafil during fexinidazole treatment and defer its use until the course is complete. If unavoidable, monitor ECG and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Frequently asked questions
Can I take Fexinidazole with Vardenafil?
MediHelp rates the interaction as major. Fexinidazole and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole prolongs the QT interval and its label advises against combining it with other QT-prolonging drugs. Vardenafil adds a small QT effect, which may increase the risk of torsades de pointes.
How serious is the interaction between Fexinidazole and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vardenafil during fexinidazole treatment and defer its use until the course is complete. If unavoidable, monitor ECG and keep potassium and magnesium normal.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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