Drug interactions
Fexinidazole + Verapamil
Severity: Moderate
Fexinidazole and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and could increase verapamil concentrations. Fexinidazole itself prolongs the QT interval, and verapamil excess can cause bradycardia and AV block.
What this interaction means in plain words
Fexinidazole and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing metabolism of verapamil; additive cardiac conduction effects are also possible.
What to do
Monitor heart rate, PR interval, QTc and blood pressure during the fexinidazole course. Reduce the verapamil dose or choose an alternative if bradycardia or conduction abnormalities occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fexinidazole and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Fexinidazole with Verapamil?
MediHelp rates the interaction as moderate. Fexinidazole and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and could increase verapamil concentrations. Fexinidazole itself prolongs the QT interval, and verapamil excess can cause bradycardia and AV block.
How serious is the interaction between Fexinidazole and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, PR interval, QTc and blood pressure during the fexinidazole course. Reduce the verapamil dose or choose an alternative if bradycardia or conduction abnormalities occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
