Drug interactions
Fexinidazole + Warfarin
Severity: Moderate
Fexinidazole and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites may inhibit CYP enzymes, and nitroimidazoles are known to potentiate warfarin. INR may rise with bleeding risk.
What this interaction means in plain words
Fexinidazole and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable inhibition of CYP-mediated warfarin metabolism, as seen with related nitroimidazoles.
What to do
Monitor INR frequently during the short fexinidazole course and for several days after, reducing warfarin if INR rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Fexinidazole with Warfarin?
MediHelp rates the interaction as moderate. Fexinidazole and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites may inhibit CYP enzymes, and nitroimidazoles are known to potentiate warfarin. INR may rise with bleeding risk.
How serious is the interaction between Fexinidazole and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR frequently during the short fexinidazole course and for several days after, reducing warfarin if INR rises.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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