Drug interactions
Fingolimod + Isoflurane
Severity: Moderate
Fingolimod and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod can slow heart rate and has been associated with QT prolongation, while isoflurane can prolong the QT interval. Together they may increase the risk of bradycardia and ventricular arrhythmias in the perioperative period.
What this interaction means in plain words
Fingolimod and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Isoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on cardiac repolarisation and heart rate.
What to do
Use continuous ECG monitoring during anesthesia in patients on fingolimod and correct potassium and magnesium beforehand. Have bradycardia treatment available and consider an alternative anesthetic in patients with baseline QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Fingolimod with Isoflurane?
MediHelp rates the interaction as moderate. Fingolimod and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod can slow heart rate and has been associated with QT prolongation, while isoflurane can prolong the QT interval. Together they may increase the risk of bradycardia and ventricular arrhythmias in the perioperative period.
How serious is the interaction between Fingolimod and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use continuous ECG monitoring during anesthesia in patients on fingolimod and correct potassium and magnesium beforehand. Have bradycardia treatment available and consider an alternative anesthetic in patients with baseline QT prolongation.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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