Drug interactions
Fingolimod + Lefamulin
Severity: Major
Fingolimod and Lefamulin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lefamulin can prolong the QT interval, especially with intravenous use, and fingolimod causes bradycardia and may affect QT. The combination raises the risk of torsades de pointes.
What this interaction means in plain words
Fingolimod and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Lefamulin belongs to Anti Bacterial.
Why it happens
Additive QTc prolongation, with fingolimod-induced bradycardia increasing arrhythmia susceptibility.
What to do
Prefer an antibiotic without QT effects. If lefamulin is needed, monitor ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Fingolimod with Lefamulin?
MediHelp rates the interaction as major. Fingolimod and Lefamulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lefamulin can prolong the QT interval, especially with intravenous use, and fingolimod causes bradycardia and may affect QT. The combination raises the risk of torsades de pointes.
How serious is the interaction between Fingolimod and Lefamulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antibiotic without QT effects. If lefamulin is needed, monitor ECG and correct potassium and magnesium.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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