Drug interactions
Fingolimod + Pitolisant
Severity: Moderate
Fingolimod and Pitolisant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pitolisant prolongs the QT interval modestly and is advised against with other QT-prolonging drugs. Fingolimod adds bradycardia and QT effects, so arrhythmia risk is increased.
What this interaction means in plain words
Fingolimod and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Pitolisant belongs to Central Nervous System.
Why it happens
Additive QTc prolongation with fingolimod-related bradycardia.
What to do
Obtain a baseline ECG and correct electrolyte abnormalities. Monitor ECG and heart rate, and consider alternatives in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Pitolisant
- Alfuzosin + Pitolisant Major
- Amiodarone + Pitolisant Major
- Amisulpride + Pitolisant Major
- Anagrelide + Pitolisant Major
- Asenapine + Pitolisant Major
- Bupropion + Pitolisant Major
Frequently asked questions
Can I take Fingolimod with Pitolisant?
MediHelp rates the interaction as moderate. Fingolimod and Pitolisant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pitolisant prolongs the QT interval modestly and is advised against with other QT-prolonging drugs. Fingolimod adds bradycardia and QT effects, so arrhythmia risk is increased.
How serious is the interaction between Fingolimod and Pitolisant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte abnormalities. Monitor ECG and heart rate, and consider alternatives in patients with other QT risk factors.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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