Drug interactions
Fingolimod + Timolol
Severity: Major
Fingolimod and Timolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes transient bradycardia and AV conduction delay after the first dose, and beta-blockers add to these effects. The combination raises the risk of symptomatic bradycardia and heart block, particularly at initiation or after treatment interruption.
What this interaction means in plain words
Fingolimod and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects.
What to do
Obtain a baseline ECG and use first-dose cardiac monitoring for at least 6 hours. Consider an alternative to the beta-blocker or seek cardiology advice before starting fingolimod.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Albuterol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Timolol?
MediHelp rates the interaction as major. Fingolimod and Timolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod causes transient bradycardia and AV conduction delay after the first dose, and beta-blockers add to these effects. The combination raises the risk of symptomatic bradycardia and heart block, particularly at initiation or after treatment interruption.
How serious is the interaction between Fingolimod and Timolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and use first-dose cardiac monitoring for at least 6 hours. Consider an alternative to the beta-blocker or seek cardiology advice before starting fingolimod.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Albuterol, Aldesleukin. The full list is on the Timolol page.
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