Drug interactions
Fingolimod + Tocilizumab
Severity: Moderate
Fingolimod and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tocilizumab and fingolimod both suppress immune responses, so combined use may raise the risk of serious infections. Tocilizumab may also mask fever and elevated CRP, delaying recognition of infection.
What this interaction means in plain words
Fingolimod and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fingolimod belongs to Central Nervous System; Tocilizumab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression through IL-6 receptor blockade and lymphocyte sequestration.
What to do
Avoid combination if possible; monitor closely for infection, including those with atypical signs, and check lymphocyte counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Fingolimod with Tocilizumab?
MediHelp rates the interaction as moderate. Fingolimod and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tocilizumab and fingolimod both suppress immune responses, so combined use may raise the risk of serious infections. Tocilizumab may also mask fever and elevated CRP, delaying recognition of infection.
How serious is the interaction between Fingolimod and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination if possible; monitor closely for infection, including those with atypical signs, and check lymphocyte counts.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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