Drug interactions
Fish oil triglycerides + Fluoxetine
Severity: Minor
Fish oil triglycerides and Fluoxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omega-3 fatty acids can modestly impair platelet aggregation, and SSRIs also increase bleeding tendency. Combined use may slightly raise bleeding risk. The effect is usually small.
What this interaction means in plain words
Fish oil triglycerides and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antiplatelet effects of omega-3 fatty acids and SSRI-induced platelet serotonin depletion.
What to do
Be alert for bruising or bleeding, particularly if other antiplatelets or anticoagulants are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fish oil triglycerides with Fluoxetine?
MediHelp rates the interaction as minor. Fish oil triglycerides and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omega-3 fatty acids can modestly impair platelet aggregation, and SSRIs also increase bleeding tendency. Combined use may slightly raise bleeding risk. The effect is usually small.
How serious is the interaction between Fish oil triglycerides and Fluoxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be alert for bruising or bleeding, particularly if other antiplatelets or anticoagulants are also used.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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