Drug interactions
Fish oil triglycerides + Indomethacin
Severity: Moderate
Fish oil triglycerides and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose omega-3 fatty acids can modestly prolong bleeding time, and indomethacin inhibits platelet function and can injure the gastric lining. Together they may add to bleeding risk, though clinically significant bleeding is uncommon.
What this interaction means in plain words
Fish oil triglycerides and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: omega-3 fatty acids reduce thromboxane A2 and platelet aggregation while NSAIDs inhibit cyclooxygenase-1.
What to do
Monitor for signs of bleeding, particularly in patients also taking anticoagulants or antiplatelet drugs. Consider gastroprotection in patients at GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Fish oil triglycerides with Indomethacin?
MediHelp rates the interaction as moderate. Fish oil triglycerides and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose omega-3 fatty acids can modestly prolong bleeding time, and indomethacin inhibits platelet function and can injure the gastric lining. Together they may add to bleeding risk, though clinically significant bleeding is uncommon.
How serious is the interaction between Fish oil triglycerides and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, particularly in patients also taking anticoagulants or antiplatelet drugs. Consider gastroprotection in patients at GI risk.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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