Drug interactions
Fish oil triglycerides + Ketoprofen
Severity: Minor
Fish oil triglycerides and Ketoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose omega-3 fatty acids have mild antiplatelet effects that may add to the bleeding tendency of NSAIDs. Clinically significant bleeding is uncommon but possible, especially with other bleeding risk factors.
What this interaction means in plain words
Fish oil triglycerides and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive reduction in platelet aggregation from omega-3 fatty acids and NSAID COX-1 inhibition.
What to do
No routine change is needed; monitor for bleeding in patients on high-dose fish oil who also have ulcer history, anticoagulants or other antiplatelet drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Fish oil triglycerides with Ketoprofen?
MediHelp rates the interaction as minor. Fish oil triglycerides and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High-dose omega-3 fatty acids have mild antiplatelet effects that may add to the bleeding tendency of NSAIDs. Clinically significant bleeding is uncommon but possible, especially with other bleeding risk factors.
How serious is the interaction between Fish oil triglycerides and Ketoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for bleeding in patients on high-dose fish oil who also have ulcer history, anticoagulants or other antiplatelet drugs.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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