Drug interactions
Fish oil triglycerides + Sertraline
Severity: Minor
Fish oil triglycerides and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose omega-3 fatty acids may mildly prolong bleeding time. Together with an SSRI, which also impairs platelet function, bleeding risk may be slightly increased, though clinically significant bleeding is uncommon.
What this interaction means in plain words
Fish oil triglycerides and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive mild antiplatelet effects of omega-3 fatty acids and SSRI-induced platelet serotonin depletion.
What to do
No routine change is needed; monitor for bruising or bleeding, particularly if other antiplatelets or anticoagulants are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Fish oil triglycerides with Sertraline?
MediHelp rates the interaction as minor. Fish oil triglycerides and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High-dose omega-3 fatty acids may mildly prolong bleeding time. Together with an SSRI, which also impairs platelet function, bleeding risk may be slightly increased, though clinically significant bleeding is uncommon.
How serious is the interaction between Fish oil triglycerides and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for bruising or bleeding, particularly if other antiplatelets or anticoagulants are also used.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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