Drug interactions
Fish oil triglycerides + Sulindac
Severity: Moderate
Fish oil triglycerides and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose omega-3 fatty acids can modestly prolong bleeding time, and NSAIDs such as sulindac impair platelet function and can cause gastrointestinal bleeding. The combination may add to bleeding risk.
What this interaction means in plain words
Fish oil triglycerides and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects: omega-3 fatty acids reduce platelet aggregability while sulindac inhibits thromboxane-dependent aggregation.
What to do
Monitor for bleeding or bruising, particularly with prolonged use or additional anticoagulants. Review the need for the NSAID if bleeding signs develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Fish oil triglycerides with Sulindac?
MediHelp rates the interaction as moderate. Fish oil triglycerides and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High-dose omega-3 fatty acids can modestly prolong bleeding time, and NSAIDs such as sulindac impair platelet function and can cause gastrointestinal bleeding. The combination may add to bleeding risk.
How serious is the interaction between Fish oil triglycerides and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding or bruising, particularly with prolonged use or additional anticoagulants. Review the need for the NSAID if bleeding signs develop.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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