Drug interactions
Flavoxate + Oxybutynin transdermal
Severity: Moderate
Flavoxate and Oxybutynin transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are used for bladder overactivity and have antimuscarinic effects. Combining them adds to the risk of dry mouth, constipation, blurred vision, urinary retention and cognitive effects, although transdermal oxybutynin gives somewhat less of the dry mouth caused by its metabolite.
What this interaction means in plain words
Flavoxate and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Avoid using two antimuscarinic bladder agents together unless clearly justified. If combined, monitor for anticholinergic adverse effects and post-void residual urine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
Frequently asked questions
Can I take Flavoxate with Oxybutynin transdermal?
MediHelp rates the interaction as moderate. Flavoxate and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are used for bladder overactivity and have antimuscarinic effects. Combining them adds to the risk of dry mouth, constipation, blurred vision, urinary retention and cognitive effects, although transdermal oxybutynin gives somewhat less of the dry mouth caused by its metabolite.
How serious is the interaction between Flavoxate and Oxybutynin transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two antimuscarinic bladder agents together unless clearly justified. If combined, monitor for anticholinergic adverse effects and post-void residual urine.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
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