Drug interactions
Flecainide + Gemtuzumab
Severity: Moderate
Flecainide and Gemtuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin has been associated with QT prolongation, which may add to flecainide's proarrhythmic potential. Chemotherapy-related vomiting and electrolyte disturbance further increase risk.
What this interaction means in plain words
Flecainide and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation.
What to do
Monitor ECG and electrolytes during treatment. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Flecainide with Gemtuzumab?
MediHelp rates the interaction as moderate. Flecainide and Gemtuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin has been associated with QT prolongation, which may add to flecainide's proarrhythmic potential. Chemotherapy-related vomiting and electrolyte disturbance further increase risk.
How serious is the interaction between Flecainide and Gemtuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes during treatment. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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