Drug interactions
Flecainide + Indapamide
Severity: Moderate
Flecainide and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide-induced hypokalemia and hypomagnesemia can heighten flecainide's proarrhythmic effects, including conduction slowing and ventricular arrhythmia. Indapamide itself may also have a QT effect.
What this interaction means in plain words
Flecainide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flecainide belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Diuretic-induced electrolyte disturbance potentiating the proarrhythmic effects of flecainide, with additive repolarization effects.
What to do
Keep potassium and magnesium in the normal range and monitor ECG. Consider an alternative diuretic if electrolytes cannot be stabilized.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Flecainide with Indapamide?
MediHelp rates the interaction as moderate. Flecainide and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide-induced hypokalemia and hypomagnesemia can heighten flecainide's proarrhythmic effects, including conduction slowing and ventricular arrhythmia. Indapamide itself may also have a QT effect.
How serious is the interaction between Flecainide and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep potassium and magnesium in the normal range and monitor ECG. Consider an alternative diuretic if electrolytes cannot be stabilized.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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