Drug interactions
Flecainide + Lofepramine
Severity: Moderate
Flecainide and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic that can slow conduction and prolong the QT interval. Combined with flecainide it may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Flecainide and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sodium channel blockade and QT prolongation.
What to do
Check ECG at baseline and after initiation, watching QRS and QTc. Prefer a non-tricyclic antidepressant in patients with structural heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Flecainide with Lofepramine?
MediHelp rates the interaction as moderate. Flecainide and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic that can slow conduction and prolong the QT interval. Combined with flecainide it may increase the risk of ventricular arrhythmias.
How serious is the interaction between Flecainide and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and after initiation, watching QRS and QTc. Prefer a non-tricyclic antidepressant in patients with structural heart disease.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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