Drug interactions
Flecainide + Protriptyline
Severity: Moderate
Flecainide and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic that can slow conduction and prolong the QT interval. With flecainide it may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Flecainide and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sodium channel blockade and QT prolongation.
What to do
Check ECG at baseline and after dose changes, observing QRS and QTc. Consider an alternative antidepressant in patients with heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Flecainide with Protriptyline?
MediHelp rates the interaction as moderate. Flecainide and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic that can slow conduction and prolong the QT interval. With flecainide it may increase the risk of ventricular arrhythmias.
How serious is the interaction between Flecainide and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG at baseline and after dose changes, observing QRS and QTc. Consider an alternative antidepressant in patients with heart disease.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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