Drug interactions
Flecainide + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Flecainide and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can cause tachycardia and QT prolongation, mostly at high systemic exposure. With flecainide, the proarrhythmic risk may be somewhat higher, though systemic exposure from inhalation is low.
What this interaction means in plain words
Flecainide and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cardiac effects: beta-agonist-related QT prolongation, hypokalemia and tachycardia combined with flecainide's proarrhythmic action.
What to do
Use at the recommended inhaled dose only and monitor heart rate, rhythm and potassium. Consider ECG monitoring in patients with structural heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Frequently asked questions
Can I take Flecainide with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Flecainide and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can cause tachycardia and QT prolongation, mostly at high systemic exposure. With flecainide, the proarrhythmic risk may be somewhat higher, though systemic exposure from inhalation is low.
How serious is the interaction between Flecainide and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use at the recommended inhaled dose only and monitor heart rate, rhythm and potassium. Consider ECG monitoring in patients with structural heart disease.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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