Drug interactions
Fleroxacin + Magnesium
Severity: Moderate
Fleroxacin and Magnesium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium cations bind fluoroquinolones such as fleroxacin in the gut and form poorly absorbed chelates. Antibiotic levels can fall and treatment may fail.
What this interaction means in plain words
Fleroxacin and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of fleroxacin by magnesium reduces its oral absorption.
What to do
Give fleroxacin at least 2 hours before or several hours after oral magnesium products. Monitor infection response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fleroxacin and Magnesium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Frequently asked questions
Can I take Fleroxacin with Magnesium?
MediHelp rates the interaction as moderate. Fleroxacin and Magnesium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium cations bind fluoroquinolones such as fleroxacin in the gut and form poorly absorbed chelates. Antibiotic levels can fall and treatment may fail.
How serious is the interaction between Fleroxacin and Magnesium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give fleroxacin at least 2 hours before or several hours after oral magnesium products. Monitor infection response.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
