Drug interactions
Fludarabine + Olaparib
Severity: Moderate
Fludarabine and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause myelosuppression, and olaparib can cause anemia, neutropenia and thrombocytopenia. Combining them can make cytopenias deeper and longer-lasting.
What this interaction means in plain words
Fludarabine and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludarabine belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive bone marrow suppression through DNA-damaging and PARP-inhibitory effects.
What to do
Monitor complete blood counts regularly and reduce or interrupt the dose of either drug for significant cytopenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludarabine
- Adenovirus types 4 and 7 live + Fludarabine Contraindicated
- Fludarabine + Pentostatin Contraindicated
- Belatacept + Fludarabine Major
- Dengue vaccine + Fludarabine Major
- Etrasimod + Fludarabine Major
- Fingolimod + Fludarabine Major
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Fludarabine with Olaparib?
MediHelp rates the interaction as moderate. Fludarabine and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause myelosuppression, and olaparib can cause anemia, neutropenia and thrombocytopenia. Combining them can make cytopenias deeper and longer-lasting.
How serious is the interaction between Fludarabine and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and reduce or interrupt the dose of either drug for significant cytopenia.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Adenovirus types 4 and 7 live, Pentostatin, Belatacept. The full list is on the Fludarabine page.
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