Drug interactions
Fludrocortisone + Gliclazide
Severity: Minor
Fludrocortisone and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone is mainly a mineralocorticoid with some glucocorticoid activity and may raise blood glucose, mostly via potassium loss. At usual replacement doses the effect on gliclazide is small.
What this interaction means in plain words
Fludrocortisone and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Gliclazide belongs to Endocrine.
Why it happens
Mild glucocorticoid activity and hypokalemia may impair insulin secretion and sensitivity.
What to do
Monitor blood glucose and serum potassium, and adjust gliclazide if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Gliclazide?
MediHelp rates the interaction as minor. Fludrocortisone and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fludrocortisone is mainly a mineralocorticoid with some glucocorticoid activity and may raise blood glucose, mostly via potassium loss. At usual replacement doses the effect on gliclazide is small.
How serious is the interaction between Fludrocortisone and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium, and adjust gliclazide if control worsens.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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