Drug interactions
Fludrocortisone + Hydrochlorothiazide-valsartan
Severity: Moderate
Fludrocortisone and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has strong mineralocorticoid activity and causes potassium loss and sodium retention. With hydrochlorothiazide this can produce marked hypokalemia, and fluid retention can counter the antihypertensive effect.
What this interaction means in plain words
Fludrocortisone and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive renal potassium excretion from mineralocorticoid receptor activation and thiazide action.
What to do
Monitor serum potassium and blood pressure regularly. Supplement potassium if needed or reassess the doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Fludrocortisone and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone has strong mineralocorticoid activity and causes potassium loss and sodium retention. With hydrochlorothiazide this can produce marked hypokalemia, and fluid retention can counter the antihypertensive effect.
How serious is the interaction between Fludrocortisone and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure regularly. Supplement potassium if needed or reassess the doses.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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