Drug interactions
Fludrocortisone + Insulin degludec-liraglutide
Severity: Moderate
Fludrocortisone and Insulin degludec-liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone is a mineralocorticoid with some glucocorticoid activity and may raise blood glucose, reducing the effect of insulin and liraglutide. The effect is generally smaller than with glucocorticoids such as prednisone.
What this interaction means in plain words
Fludrocortisone and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Insulin degludec-liraglutide belongs to Endocrine.
Why it happens
Corticosteroid activity promotes hyperglycemia and insulin resistance, antagonizing antidiabetic drugs.
What to do
Monitor blood glucose after fludrocortisone is started or its dose changed. Increase the antidiabetic dose if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin degludec-liraglutide
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Insulin degludec-liraglutide?
MediHelp rates the interaction as moderate. Fludrocortisone and Insulin degludec-liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone is a mineralocorticoid with some glucocorticoid activity and may raise blood glucose, reducing the effect of insulin and liraglutide. The effect is generally smaller than with glucocorticoids such as prednisone.
How serious is the interaction between Fludrocortisone and Insulin degludec-liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after fludrocortisone is started or its dose changed. Increase the antidiabetic dose if hyperglycemia develops.
What other medicines interact with Insulin degludec-liraglutide?
MediHelp also lists interactions of Insulin degludec-liraglutide with, for example, Albiglutide, Chlorpropamide, Clozapine. The full list is on the Insulin degludec-liraglutide page.
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