Drug interactions
Fludrocortisone + Insulin degludec
Severity: Moderate
Fludrocortisone and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has some glucocorticoid activity and may raise blood glucose, partly offsetting insulin degludec. The effect is generally modest at usual replacement doses but can matter in patients with diabetes.
What this interaction means in plain words
Fludrocortisone and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Insulin degludec belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: corticosteroid activity promotes gluconeogenesis and insulin resistance.
What to do
Monitor blood glucose more frequently when fludrocortisone is started, changed or stopped. Adjust the insulin dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fludrocortisone
Other interactions of Insulin degludec
Frequently asked questions
Can I take Fludrocortisone with Insulin degludec?
MediHelp rates the interaction as moderate. Fludrocortisone and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fludrocortisone has some glucocorticoid activity and may raise blood glucose, partly offsetting insulin degludec. The effect is generally modest at usual replacement doses but can matter in patients with diabetes.
How serious is the interaction between Fludrocortisone and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when fludrocortisone is started, changed or stopped. Adjust the insulin dose as required.
What other medicines interact with Fludrocortisone?
MediHelp also lists interactions of Fludrocortisone with, for example, Mifepristone, Aldesleukin, Amphotericin b. The full list is on the Fludrocortisone page.
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