Drug interactions
Fludrocortisone + Meclofenamic acid
Severity: Moderate
Fludrocortisone and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the risk of gastric irritation and ulceration. Fludrocortisone's mineralocorticoid effect may also add to fluid retention with the NSAID.
What this interaction means in plain words
Fludrocortisone and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal injury, and combined sodium and fluid retention.
What to do
Monitor for GI symptoms and consider gastroprotection if used long term. Check blood pressure, edema and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Meclofenamic acid?
MediHelp rates the interaction as moderate. Fludrocortisone and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the risk of gastric irritation and ulceration. Fludrocortisone's mineralocorticoid effect may also add to fluid retention with the NSAID.
How serious is the interaction between Fludrocortisone and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI symptoms and consider gastroprotection if used long term. Check blood pressure, edema and electrolytes.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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