Drug interactions
Fludrocortisone + Meloxicam
Severity: Moderate
Fludrocortisone and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs raise the risk of gastrointestinal ulceration and bleeding. Fludrocortisone is primarily mineralocorticoid, so the GI risk is lower than with glucocorticoids, but fluid retention may also counter the NSAID effect on blood pressure.
What this interaction means in plain words
Fludrocortisone and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Meloxicam belongs to Musculoskeletal.
Why it happens
Additive mucosal injury from NSAID prostaglandin inhibition and corticosteroid effects, plus additive sodium and fluid retention.
What to do
Use the lowest effective meloxicam dose and consider gastroprotection in at-risk patients. Monitor blood pressure, edema and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Meloxicam?
MediHelp rates the interaction as moderate. Fludrocortisone and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs raise the risk of gastrointestinal ulceration and bleeding. Fludrocortisone is primarily mineralocorticoid, so the GI risk is lower than with glucocorticoids, but fluid retention may also counter the NSAID effect on blood pressure.
How serious is the interaction between Fludrocortisone and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective meloxicam dose and consider gastroprotection in at-risk patients. Monitor blood pressure, edema and electrolytes.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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