Drug interactions
Fludrocortisone + Metformin-repaglinide
Severity: Minor
Fludrocortisone and Metformin-repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone has mild glucocorticoid activity and may raise blood glucose, which can reduce antidiabetic effect. Any enzyme induction effect on repaglinide is theoretical and likely small at usual doses.
What this interaction means in plain words
Fludrocortisone and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Metformin-repaglinide belongs to Endocrine.
Why it happens
Glucocorticoid-mediated hyperglycemia, with possible minor CYP3A4 induction.
What to do
Monitor blood glucose when starting or changing fludrocortisone and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-repaglinide
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Metformin-repaglinide?
MediHelp rates the interaction as minor. Fludrocortisone and Metformin-repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fludrocortisone has mild glucocorticoid activity and may raise blood glucose, which can reduce antidiabetic effect. Any enzyme induction effect on repaglinide is theoretical and likely small at usual doses.
How serious is the interaction between Fludrocortisone and Metformin-repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing fludrocortisone and adjust antidiabetic therapy if control worsens.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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