Drug interactions
Fludrocortisone + Miconazole
Severity: Minor
Fludrocortisone and Miconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fludrocortisone is partly metabolized by CYP3A4, and inhibitors may increase mineralocorticoid exposure. With vaginal miconazole the effect is likely small. Excess effect could cause fluid retention, hypertension and hypokalemia.
What this interaction means in plain words
Fludrocortisone and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fludrocortisone belongs to Endocrine; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4, slightly reducing fludrocortisone metabolism.
What to do
No routine change is needed. Monitor blood pressure, edema and serum potassium if miconazole is prolonged or repeated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Miconazole
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Miconazole?
MediHelp rates the interaction as minor. Fludrocortisone and Miconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fludrocortisone is partly metabolized by CYP3A4, and inhibitors may increase mineralocorticoid exposure. With vaginal miconazole the effect is likely small. Excess effect could cause fluid retention, hypertension and hypokalemia.
How serious is the interaction between Fludrocortisone and Miconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor blood pressure, edema and serum potassium if miconazole is prolonged or repeated.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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