Drug interactions
Fludrocortisone + Naproxen
Severity: Moderate
Fludrocortisone and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs increase the risk of peptic ulceration and gastrointestinal bleeding. Fludrocortisone also causes sodium and fluid retention, which can worsen NSAID-related blood pressure elevation and edema.
What this interaction means in plain words
Fludrocortisone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Naproxen belongs to Musculoskeletal.
Why it happens
Additive gastric mucosal injury from NSAID prostaglandin suppression and corticosteroid effects, plus mineralocorticoid-mediated fluid retention.
What to do
Consider a proton pump inhibitor in at-risk patients and monitor blood pressure, edema and signs of GI bleeding. Keep the naproxen course short.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Naproxen?
MediHelp rates the interaction as moderate. Fludrocortisone and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs increase the risk of peptic ulceration and gastrointestinal bleeding. Fludrocortisone also causes sodium and fluid retention, which can worsen NSAID-related blood pressure elevation and edema.
How serious is the interaction between Fludrocortisone and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor in at-risk patients and monitor blood pressure, edema and signs of GI bleeding. Keep the naproxen course short.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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