Drug interactions
Fludrocortisone + Ofloxacin
Severity: Moderate
Fludrocortisone and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent corticosteroid and fluoroquinolone use raises the risk of tendinitis and tendon rupture. Fludrocortisone has mainly mineralocorticoid activity at usual doses, so the risk is probably lower than with glucocorticoids, but it still applies.
What this interaction means in plain words
Fludrocortisone and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
Why it happens
Corticosteroids and fluoroquinolones both impair tendon collagen turnover, producing additive tendon toxicity.
What to do
Counsel the patient to report tendon pain or swelling promptly and stop ofloxacin if this occurs. Consider a non-quinolone antibiotic in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Ofloxacin?
MediHelp rates the interaction as moderate. Fludrocortisone and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent corticosteroid and fluoroquinolone use raises the risk of tendinitis and tendon rupture. Fludrocortisone has mainly mineralocorticoid activity at usual doses, so the risk is probably lower than with glucocorticoids, but it still applies.
How serious is the interaction between Fludrocortisone and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report tendon pain or swelling promptly and stop ofloxacin if this occurs. Consider a non-quinolone antibiotic in older patients.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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