Drug interactions
Fludrocortisone + Oxcarbazepine
Severity: Moderate
Fludrocortisone and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce fludrocortisone effect, potentially causing inadequate mineralocorticoid action with hypotension or electrolyte disturbance. The effect is predicted from enzyme induction rather than well characterized.
What this interaction means in plain words
Fludrocortisone and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fludrocortisone belongs to Endocrine; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine induces CYP3A4, increasing fludrocortisone metabolism.
What to do
Monitor blood pressure, serum sodium and potassium after starting or stopping oxcarbazepine. Increase the fludrocortisone dose if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Fludrocortisone with Oxcarbazepine?
MediHelp rates the interaction as moderate. Fludrocortisone and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce fludrocortisone effect, potentially causing inadequate mineralocorticoid action with hypotension or electrolyte disturbance. The effect is predicted from enzyme induction rather than well characterized.
How serious is the interaction between Fludrocortisone and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum sodium and potassium after starting or stopping oxcarbazepine. Increase the fludrocortisone dose if response is inadequate.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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